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UNIVERSITY OF WASHINGTON FRIDAY HARBOR LABS

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Related pages

JAZZ at the LABS

Jazz at the Labs supports science in the classroom (2006)
posted 06/05/06

Not your typical science classroom (jazz preview 2005)
posted 05/25/05

Jazz at the Labs supports science in the classroom (2004)
posted 06/08/04

OPEN HOUSE

Open House 2007
posted 05/21/2007

Open House 2005
posted 05/09/05

Open House 2003
posted 05/04/03

Arthur Whiteley

Helen Riaboff Whiteley Center

Global impacts of "Bug Station's" century of research
posted 07/19/04

100 Years of Exploration and Discovery - University of Washington Friday Harbor Labs Centennial Exhibit
posted 05/17/04

Centennial celebration included dedication of the Centennial
posted 05/05/03

Ellis gift celebrated

Helen Riaboff Whiteley Center
posted 05/05/02

NECROPSY STORY:

Research at UW FHL leads to Nobel Prize

posted 10/09/2008
Osamu Shimomura of the Marine Biological Laboratory in Woods Hole, Massachusetts; Martin Chalfie of Columbia University; and Roger Tsien of the University of California at San Diego won for the discovery and development of the green fluorescent protein GFP.

GFP was first observed in 1961- 1962, by Dr. Shimomura at UW Friday Harbor Laboratories. Much of his research on GFP took place at Friday Harbor Laboratories.

Since then, the protein has become one of the most important tools in contemporary bioscience, the foundation said. Using GFP, researchers have developed ways to watch processes that were previously invisible, like the development of nerve cells or how cancer cells spread.

In 2004, during its Centennial year celebrations, Friday Harbor Laboratories hosted an international symposium on 'Calcium-Regulated Photoproteins and Green-Fluorescent Proteins' honoring Dr. Shimomura. In attendance and presenting papers were his co-Nobel Prize winners, Martin Chalfie and Roger Tsien .

"I started the study of the Aequorea bioluminescence in 1961 with Dr. Frank Johnson, at the Friday Harbor Laboratory, University of Washington, assisted in various ways by Dr. Robert Fernald, Director of the Laboratory" said Dr. Shimomura in his presentation at the symposium.

In the Friday Harbor Labs timeline that she developed for the Centenial Celebration in 2004, Claudia Mills wrote the following:

1961-1962 - Frank Johnson and Osamu Shimomura from Princeton isolate the calcium-sensitive photoprotein aequorin and a byproduct green fluorescent protein (eventually known as GFP) from the jellyfish Aequorea at the Laboratories. Dr. Johnson continues with this project through the 1960s and Dr. Shimomura continues to visit FHL during the summer to collect and purify aequorin for more than two decades. Aequorin, originally from Friday Harbor jellyfish, is eventually characterized, cloned and used in laboratories throughout the world as a highly sensitive calcium probe for studying the role of calcium in intracellular processes. The green fluorescent protein (GFP) is also eventually cloned and widely used as a genetic marker protein, making it possible to insert fluorescence-tagged proteins into cells and to produce entire organisms that fluoresce under UV illumination.

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